6-((tert-butoxycarbonylamino)methyl)picolinic acid synthesis
- Product Name:6-((tert-butoxycarbonylamino)methyl)picolinic acid
- CAS Number:171670-07-8
- Molecular formula:C12H16N2O4
- Molecular Weight:252.27
![2-Pyridinecarboxylic acid, 6-[[bis[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, ethyl ester](/CAS/20210305/GIF/1258831-91-2.gif)
![2-Pyridinecarboxylic acid, 6-[[bis[(1,1-dimethylethoxy)carbonyl]amino]methyl]-](/CAS/20210305/GIF/874619-36-0.gif)
Yield:171670-07-8 32% ，874619-36-0 57%
Reaction Conditions:
Stage #1: ethyl 6-{[bis(tert-butoxycarbonyl)amino]methyl}pyridine-2-carboxylatewith water;triethylamine;lithium bromide in acetonitrile at 20; for 24 h;
Stage #2: with hydrogenchloride;water in ethyl acetate;acetonitrile; pH=2 - 3;
References:
Irfan Ashiq, Muhammad;Tesfatsion, Biniam F.;Gaggini, Francesca;Dixon, Sally;Kilburn, Jeremy D. [Chemistry - A European Journal,2010,vol. 16,# 41,p. 12387 - 12397] Location in patent:experimental part
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