1,2-Benzisothiazol-3(2H)-one, 6-chloro-2-methyl-, 1,1-dioxide synthesis
- Product Name:1,2-Benzisothiazol-3(2H)-one, 6-chloro-2-methyl-, 1,1-dioxide
- CAS Number:6202-68-2
- Molecular formula:C8H6ClNO3S
- Molecular Weight:231.66
![6-CHLORO-1,1-DIOXO-1,2-DIHYDRO-1-BENZO[D]ISOTHIAZOL-3-ONE](/StructureFile/ChemBookStructure6/GIF/CB6493556.gif)
Yield:6202-68-2 340 mg
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 80; for 12 h;Sealed tube;
Steps:
385.B Step B.6-Chloro-2-methyl-1,1-dioxo-1,2-benzothiazol-3-one
A mixture of 6-chloro-1,1-dioxo-1,2-benzothiazol-3-one (400 mg, 1.84 mmol), iodomethane (391 mg, 2.76 mmol) and cesium carbonate (898 mg, 2.76 mmol) in N,N-dimethylformamide (6 ml) was stirred at 80 oC in a sealed tube for 12h. Water was added and the reaction was extracted with ethyl acetate (20 ml). The organic phase was isolated, washed with brine, dried over sodium sulfate and concentrated to afford 6-chloro-2-methyl-1,1-dioxo-1,2-benzothiazol-3-one (340 mg) as a brown solid, which was used without further purification. MS (ESI): m/z =232.1 [M+1]+.
References:
WO2017/108723,2017,A2 Location in patent:Page/Page column 621
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