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ChemicalBook CAS DataBase List 7-Bromo-1-methyl-1H-indole 97%
280752-68-3

7-Bromo-1-methyl-1H-indole 97% synthesis

4synthesis methods
-

Yield:280752-68-3 92%

Reaction Conditions:

Stage #1: 7-bromo-1H-indolewith sodium hydride in tetrahydrofuran;mineral oil at 0 - 20; for 1.75 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran;mineral oil at 0 - 20;Inert atmosphere;

References:

Tolnai, Gergely L.;Ganss, Stephanie;Brand, Jonathan P.;Waser, Jerome [Organic Letters,2013,vol. 15,# 1,p. 112 - 115] Location in patent:supporting information