7-HYDROXY-3-METHYL-2H-CHROMEN-2-ONE synthesis

11synthesis methods

Product Name:7-HYDROXY-3-METHYL-2H-CHROMEN-2-ONE
CAS Number:4069-67-4
Molecular formula:C10H8O3
Molecular Weight:176.17

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Yield: 85%

Reaction Conditions:

with piperidine;sodium proprionate at 170;

Steps:

3 7-Hydroxy-3-methyl-2H-chromen-2-one
To a 10 mL RB flask was added 2,4-dihydroxybenzaldehyde (1 g), sodium propionate (1.5 g), piperidine (0.1 mL) and propionic anhydride (2.5 mL).
The mixture was heated to 170° C., poured into ice water, and 1N HCl was added to bring the pH to ca. 3.
The solid was collected by filtration, mixed with 1 mL of sulfuric acid, and poured into ice water.
The solid was collected, washed with H₂O and ether, and dried under vacuum. Yield: 85%.

References:

Colossus Biopharma Consultants Co., Ltd.;Mendoza, Jose US2018/228923, 2018, A1 Location in patent:Paragraph 0220; 0221

137-40-6 Synthesis