7-Methoxy-8-hydroxy-4-MethylcouMarin synthesis
- Product Name:7-Methoxy-8-hydroxy-4-MethylcouMarin
- CAS Number:22084-94-2
- Molecular formula:C11H10O4
- Molecular Weight:206.19
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Yield:22084-94-2 268 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 5; for 3.5 h;Inert atmosphere;
Steps:
5 Preparation of 4-methyl-7-methoxy-8-hydroxycoumarin (II-ab)
Weigh 4-methyl-7,8-dihydroxycoumarin 500mg in three-necked flask,Add 5 mL of N, N-dimethylformamide to dissolve the sample,1.5 g of potassium carbonate was added,After stirring for 15 minutes,450 μL of methyl iodide was added dropwise,5 reaction,TLC monitors the progress of the reaction,3.5h after the reaction was over,Quench the reaction with water,Add hydrochloric acid to adjust the pH to about 3,Ethyl acetate extraction (50 mL x 3),The combined ethyl acetate phase,Saturated brine twice,The organic phase was distilled under reduced pressure to remove ethyl acetate,That is crude,The crude product was separated by silica gel column,Mobile phase V petroleum ether: V dichloromethane: V acetone = 2: 1: 0.2,The solvent was distilled off under reduced pressure,Vacuum dried,268 mg of a white solid was obtained,
References:
CN106518826,2017,A Location in patent:Paragraph 0044; 0045; 0046
2107-77-9
141 suppliers
$14.60/100mg
77-78-1
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$22.00/25g
22084-94-2
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