ChemicalBook CAS DataBase List 7-Methoxyflavone

7-Methoxyflavone synthesis

10synthesis methods

Product Name:7-Methoxyflavone
CAS Number:22395-22-8
Molecular formula:C16H12O3
Molecular Weight:252.26

552-41-0
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$5.00/1g

100-52-7 Synthesis

100-52-7
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$17.30/2g

22395-22-8
152 suppliers
$11.00/1g

Yield:22395-22-8 88%

Reaction Conditions:

with pyrrolidine;iodine in dimethyl sulfoxide at 150; for 10 h;

Steps:

Typical procedure for the synthesis of flavones:
General procedure: 2'-Hydroxyacetophenone (1 mmol) and substituted aromatic aldehyde (1 mmol) were mixed together along with pyrrolidine (0.5 mmol) and iodine (0.05 mmol) in DMSO solvent (10 mL). The resulting mixture was then heated at 150 °C for the given time. After completion of reaction (monitored by TLC) the reaction mass was allowed to cool and diluted with ethyl acetate (20 mL). Resulting solution was then washed with water and saturated sodium thiosulfate solution followed by drying over anhydrous sodium sulfate and concentrating under reduced pressure to furnish the crude product. The residue obtained was purified by column chromatography using petroleum ether-ethyl acetate as an eluent to afford flavones (3a-r).

References:

Naik, Mayuri M.;Tilve, Santosh G.;Kamat, Vijayendra P. [Tetrahedron Letters,2014,vol. 55,# 22,p. 3340 - 3343]

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