ChemicalBook CAS DataBase List 5,7-DIMETHOXYFLAVONE

5,7-DIMETHOXYFLAVONE synthesis

12synthesis methods

Product Name:5,7-DIMETHOXYFLAVONE
CAS Number:21392-57-4
Molecular formula:C17H14O4
Molecular Weight:282.29

1775-97-9
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$25.00/500μg

21392-57-4
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$60.00/50 mg

Yield:21392-57-4 81%

Reaction Conditions:

with iodine in dimethyl sulfoxideReflux;

Steps:

Synthesis of Peralkylated Flavone Derivatives (7); General Procedure
General procedure: To a solution of the corresponding chalcone (6) in dimethyl sulfoxide (DMSO; 2-5 mL per 1.0 mmol) was added iodine (8 mol%) and the mixture was mildly refluxed until complete conversion (TLC). After completion, the mixture was poured into 10% aq. Na₂S₂O₃ and stirred. The precipitate was collected by filtration, was washed with water and hexane. The crude product was recrystallized from ethanol-water (1:1) to yield the pure products.

References:

Sipos, Zoltán;Kónya, Krisztina [Synthesis,2018,vol. 50,# 8,p. 1610 - 1620] Location in patent:supporting information

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