1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine synthesis
- Product Name:1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine
- CAS Number:763111-49-5
- Molecular formula:C21H21FN4O2
- Molecular Weight:380.42
763114-26-7
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Yield: 68%
Reaction Conditions:
in tert-butyl 1,4-diazepine-1-carboxylate
Steps:
1.d d.
d. Synthesis of 4-[3-([1,4]diazepane-1-carbonyl)-4 -fluorobenzyl]-2H-phthalazin-1-one (4) The synthesis was carried out according to the method described in (a) above using 2-fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid (B) and tert-butyl 1-homopiperazinecarboxylate to yield 4-[3-([1,4]diazepane-1-carbonyl)benzyl]-2H-phthalazin-1-one (4) as a yellow crystalline solid (5.3 g, 68%); m/z [M+1]+ 381 (97% purity); δH 2.6-3.8 (10H, m), 4.4 (2H, s), 7.2-7.5 (3H, m), 7.7-8.0 (3H, m), 8.2-8.3 (1H, m), 12.6 (1H, s).
References:
Kudos Pharmaceuticals Limited;Maybridge Limited US2005/59663, 2005, A1
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112275-50-0
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112275-50-0
239 suppliers
$9.00/1g
763111-49-5
14 suppliers
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