tert-butyl 4-(4-(ethoxycarbonyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate synthesis
- Product Name:tert-butyl 4-(4-(ethoxycarbonyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
- CAS Number:782493-64-5
- Molecular formula:C16H25N3O4
- Molecular Weight:323.39
5932-27-4
210 suppliers
$16.00/1g
141699-59-4
237 suppliers
$6.00/1g
782493-64-5
17 suppliers
inquiry
Yield: 87%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 5 - 90;
Steps:
2 Step 2: Tert-butyl 4-(4-(ethoxycarbonyl)- I H-pyrazol- l-yl) piperidine- I -carboxyl ate:
To a stirred solution of ethyl-I-H pyrazole carboxylate (5.0 g, 3.7mmol) in DMF (50 mL),Cs2CO3 (23 g, 71.3Smmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-I-carboxylate(9.9 g, 35.6 mmol) were added at 5 °C and reaction mixture was stirred at 90 °C overnight.The completion of the reaction was confirmed by TLC. The reaction mixture was pouredinto ice cold water. The resulting solid was filtered, washed with water (50 mL) and driedunder reduced pressure. It was used in the next step without any further purification. Yield:87% (10 g, off white solid). 1H NMR (400 MHz, DMSO-d6 : 6 8.39 (5, IH), 7.87 (5, IH),4.45-4.39 (m, IH), 4.21 (q, J= 7.2 Hz, 2H), 4.05-4.02 (m, 2H), 2.01-1.98 (m, 2H), 1.85-1.78 (m, 2H), 1.42 (5, 9H), 1.26 (t, J = 7.2 Hz, 3H). LCMS: (Method A) 222.0 (M-Boc), Rt. 2.77 mm, 92.86% (Max).
References:
ASCENEURON S. A.;QUATTROPANI, Anna;KULKARNI, Santosh, S.;GIRI, Awadut, Gajendra WO2017/144633, 2017, A1 Location in patent:Page/Page column 105
37622-90-5
340 suppliers
$6.00/1g
141699-59-4
237 suppliers
$6.00/1g
782493-64-5
17 suppliers
inquiry
37622-90-5
340 suppliers
$6.00/1g
118811-07-7
120 suppliers
$9.00/250mg
782493-64-5
17 suppliers
inquiry
37622-90-5
340 suppliers
$6.00/1g
109384-19-2
472 suppliers
$5.00/1g
782493-64-5
17 suppliers
inquiry
109384-19-2
472 suppliers
$5.00/1g
782493-64-5
17 suppliers
inquiry