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1-(2-thienylmethyl)piperidin-4-amine(SALTDATA: 2HCl) synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

with hydroxylamine in sodium hydroxide;

Steps:

21.c N-(2-Thienylmethyl)-4-(4-nitrophthalimino)piperidine

c. N-(2-Thienylmethyl)-4-piperidone is reacted with hydroxylamine, followed by nickel, aluminium alloy in 30% sodium hydroxide solution, in a similar manner to that described in Example 19 to give 4-amino-N-(2-thienylmethyl)piperidine.

References:

US4053615,1977,A