2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride synthesis
- Product Name:2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
- CAS Number:86604-75-3
- Molecular formula:C9H13Cl2NO
- Molecular Weight:222.11
86604-78-6
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86604-75-3
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Yield:86604-75-3 100%
Reaction Conditions:
with thionyl chloride in dichloromethane at 20; for 1 h;
Steps:
[2-CHLOROMETHYL-3SS-DIMETHYL-4-METHOXYPYRIDINE] hydrochloride
To a solution [OF 4-METHOXY-3, 5-DIMETHYLPYRIDINEMETHANOL] (25.1 g, 0.15 mol) in dichloromethane (400 mL) was added a solution of thionyl chloride (18.8 g, 0. [158] mol) in dichloromethane (100 mL) over 30 min at room temperature under argon. After an additional 30 min of stirring at room temperature, the solvent was removed under reduced pressure. The solid residue was suspended in hexanes (200 mL) and filtered. The solid was washed with hexanes (50 mL) and air-dried to give 33.3 g (100%) of the title compound as a white solid.
References:
WO2004/9583,2004,A2 Location in patent:Page 156
84006-10-0
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86604-75-3
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96300-88-8
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91219-90-8
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86604-75-3
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86604-75-3
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