TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE
- CAS Number:873924-08-4
- Molecular formula:C15H25NO3
- Molecular Weight:267.36
![3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester](/CAS/GIF/873924-07-3.gif)
873924-07-3
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873924-08-4
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Yield:873924-08-4 99%
Reaction Conditions:
with hydrogen;palladium-on-charcoal in methanol at 25; for 16 h;Product distribution / selectivity;Inert atmosphere;
Steps:
5
Step-5: tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate A solution of tert-butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate (15.09 mmol, 1.0 eq.) in MeOH (40 ml) was degassed with argon for 15 min and then Pd-C (1.0 g) was added. The reaction mixture was stirred under H2 balloon pressure at 25° C. for 16 h. The mixture was filtered through celite and filtrate concentrated to give the desired product as a light yellow sticky solid. Yield: >99%
References:
Gruenenthal GmbH US2010/249095, 2010, A1 Location in patent:Page/Page column 127
24424-99-5
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$13.50/25G
![3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, phenylMethyl ester](/CAS/GIF/189333-18-4.gif)
189333-18-4
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873924-08-4
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24424-99-5
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![3-Aza-spiro[5.5]undecan-9-one hydrochloride](/CAS/GIF/CB13126094.gif)
1225437-09-1
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873924-08-4
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137076-22-3
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873924-08-4
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123855-51-6
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873924-08-4
114 suppliers
$54.00/100mg