Benzene, 1-bromo-2-fluoro-4-phenoxy- synthesis
- Product Name:Benzene, 1-bromo-2-fluoro-4-phenoxy-
- CAS Number:1138557-58-0
- Molecular formula:C12H8BrFO
- Molecular Weight:267.09
51067-38-0
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Yield:1138557-58-0 550 g
Reaction Conditions:
with oxygen;copper diacetate;triethylamine in dichloromethane at 0;Molecular sieve;
Steps:
17 Example 17: Preparation of l-bromo-2-fluoro-4-phenoxybenzene
To a stirred solution of 4-bromo-3-fluorophenol (500 g, 2.6 mol) in DCM (500 ml) was added phenylboronic acid (638 g, 5.23 mol), copper (II) acetate (575 g, 2.8 mol) and molecular sieves 4 (500 g). The resulting mixture was cooled to 0°C, and triethyl amine (1095 ml, 7.85 mol) was added drop wise. The reaction mixture was then stirred overnight under oxygen atmosphere. DCM was then removed under vacuum and n-hexane (5000 ml) was added and stirred at 50-55°C for one hour and then filtered hot. The filtered cake was washed with hot n-hexane. The combined filtrate was washed with 4M HCI, 4M NaOH, water and brine. The organic layer was then concentrated under vacuum to give title compound. Yield 550g.
References:
WO2021/38540,2021,A1 Location in patent:Page/Page column 133-134
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