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ChemicalBook CAS DataBase List bis(4-fluorophenyl)-Phosphine oxide

bis(4-fluorophenyl)-Phosphine oxide synthesis

7synthesis methods
-

Yield:94940-35-9 96%

Reaction Conditions:

Stage #1: 1-Bromo-4-fluorobenzenewith magnesium in tetrahydrofuran at 20; for 2 h;
Stage #2: with phosphonic acid diethyl ester in tetrahydrofuran;

References:

Zhang, Dapeng;Lian, Mingming;Liu, Jia;Tang, Shukun;Liu, Guangzhi;Ma, Cunfei;Meng, Qingwei;Peng, Haisheng;Zhu, Daling [Organic Letters,2019,vol. 21,# 8,p. 2597 - 2601] Location in patent:supporting information