ChemicalBook CAS DataBase List Cyclophosphamide

Cyclophosphamide synthesis

5synthesis methods

Product Name:Cyclophosphamide
CAS Number:50-18-0
Molecular formula:C7H15Cl2N2O2P
Molecular Weight:261.09

Cyclophosphamide, 2-[bis-(2-chloroethyl)amino]tetrahydro- 2H-1,3,2-oxazaphosphorin-2-oxide (30.2.1.15), is made by reacting bis(2-chloroethyl)amine with phosphorous oxychloride, giving N,N-bis-(2-chloroethyl)dichlorophosphoramide (30.2.1.14), which upon subsequent reaction with 3-aminopropanol is transformed into cyclophosphamide (30.2.1.15).

107-06-2 Synthesis

107-06-2
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5638-58-4 Synthesis

2-Chloro-1,3,2-oxazaphosphacyclohexane 2-oxide

5638-58-4
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50-18-0
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Yield:50-18-0 92.3%

Reaction Conditions:

with ammonia at 120; under 3040.2 Torr; for 2 h;Molecular sieve;

Steps:

1; 2; 3

(2) 10 g of 2-chloro-2-oxo-[1.3.2]-oxazaphosphinane was transferred to a pressure reaction bottle.Add 50g of dichloroethane and 10g of 5a molecular sieve (used after activation at 300 °C),Passing ammonia gas, maintaining at 4 atmospheres, heating to 120 ° C, reacting for 2 hours, the reaction is completed;(3) After filtering the reaction mixture, adding ice-water mixture, stirring for 30 minutes, separating the organic phase, washing with 10% hydrochloric acid solution, separating the organic phase, controlling the water bath temperature to 50 ° C, and concentrating the organic phase to dryness under reduced pressure. Acetone was added, the temperature was raised to 40 ° C to dissolve, and then the temperature was lowered to 5 ° C or less, and the crystal was decanted for 5 hours, and filtered to obtain a white crystalline solid, which was dried to obtain cyclophosphamide.

References:

CN109535201,2019,A Location in patent:Paragraph 0026; 0029; 0030; 0033-0037

821-48-7 Synthesis