D-1-N-Boc-prolinamide synthesis
- Product Name:D-1-N-Boc-prolinamide
- CAS Number:35150-07-3
- Molecular formula:C10H18N2O3
- Molecular Weight:214.26
15761-39-4
35150-07-3
GENERAL METHOD: BOC-L-proline (1.00 g, 4.65 mmol), di-tert-butyl dicarbonate (1.52 g, 6.97 mmol), ammonium bicarbonate (0.55 g, 6.97 mmol), and pyridine (1.0 mL) were dissolved in dioxane (20 mL), and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the product was extracted with dichloromethane, the organic phase was washed sequentially with 1 M hydrochloric acid and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the concentrate was added n-hexane (100 mL) and sonication prompted the product to precipitate as a white solid to afford N-tert-butoxycarbonyl-L-prolinamide (0.85 g, 85% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.37-4.34 (m, 1H), 3.47-3.36 (m, 2H), 2.07-1.85 (m, 4H), 1.49 (s, 9H). Mass spectrum (ESI) m/z 215 [M + H]+.
24424-99-5
865 suppliers
$13.50/25G
7531-52-4
683 suppliers
$6.00/5g
35150-07-3
257 suppliers
$5.00/1g
15761-39-4
610 suppliers
$5.00/10g
35150-07-3
257 suppliers
$5.00/1g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
35150-07-3
257 suppliers
$5.00/1g
59936-29-7
237 suppliers
$6.00/5g
35150-07-3
257 suppliers
$5.00/1g