D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE synthesis
- Product Name:D/L-ALPHA-PHENYLGLYCINEETHYLESTER HYDROCHLORIDE
- CAS Number:72651-17-3
- Molecular formula:C10H14ClNO2
- Molecular Weight:215.6767
Yield:72651-17-3 96.4%
Reaction Conditions:
with thionyl chlorideCooling with ice;Reflux;
Steps:
4.2. General procedure for the synthesis of intermediate (2)
Thionyl chloride (3.0 equiv) was slowly dissolved into the absoluteethanol solution under ice bath conditions. Next, phenylglycine(1.0 equiv) was added into the mixture solution in batches,and the reaction solution was heated to reflux condition for 4e5h.After the reaction completion as monitored by TLC, the reactionmixture was concentrated to produce the white solids underreduced pressure (2).th
References:
Liu, Wenxia;Sun, Zhuang;An, Yunfei;Liu, Yating;Fan, Haiyan;Han, Jun;Sun, Bin [European Journal of Medicinal Chemistry,2022,vol. 228,art. no. 113972]
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81477-96-5
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