DIALLYLETHANOLAMINE synthesis

5synthesis methods

Product Name:DIALLYLETHANOLAMINE
CAS Number:17719-79-8
Molecular formula:C8H15NO
Molecular Weight:141.21

124-02-7 Synthesis

124-02-7
237 suppliers
$14.00/5mL

107-07-3
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$21.53/50ml

17719-79-8
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$90.00/100mg

Yield:17719-79-8 49%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20;Inert atmosphere;

Steps:

2-(Diallylamino)ethanol (32)

A mixture of diallylamine (1.27 mL, 10.29 mmol), 2-chloroethanol (0.89 mL, 10.29 mmol), and K₂CO₃ (14.2 g, 103 mmol) in DMF (20 mL/g) was vigorously stirred at room temperature under N₂. After completion, H₂O was added and extracted with Et₂O. The combined organic layers were washed with brine solution and dried over Na₂SO₄. After removal of the solvent under reduced pressure, the crude product was purified by column chromatography (silica gel, 1-3% CHCl₃/MeOH/1% NH₄OH). Yield 49% (0.71 g); MS ESI m/z = 142 (M+H⁺).

References:

Stavitskaya, Lidiya;Shim, Jihyun;Healy, Jason R.;Matsumoto, Rae R.;MacKerell Jr., Alexander D.;Coop, Andrew [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 14,p. 4556 - 4563] Location in patent:experimental part

141-43-5 Synthesis