ChemicalBook CAS DataBase List dimethyl(2-phenoxyethyl)amine

dimethyl(2-phenoxyethyl)amine synthesis

12synthesis methods

Product Name:dimethyl(2-phenoxyethyl)amine
CAS Number:13468-02-5
Molecular formula:C10H15NO
Molecular Weight:165.23

2-Dimethylaminoethyl chloride hydrochloride

4584-46-7
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$15.50/5g

108-95-2 Synthesis

108-95-2
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13468-02-5
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$11.00/1g

Yield: 86%

Reaction Conditions:

with potassium hydroxide in ethanol;water at 55 - 60; for 4 h;Reagent/catalyst;

Steps:

1.1 First Step
The phenol 94g (1mol), potassium hydroxide 117.6g (2.1mol) was added 600ml ethanol and stirred to dissolve, temperature at 55 ~ 60 reaction slowly added dropwiseN, N- dimethyl-chloroethane hydrochloride 158g (1.1mol, was dissolved in 300g water), the addition was complete reaction was continued for 4 hours; the reaction was completed, recovering ethanol, then extracted twice with dichloromethane, combined, washed with water and concentrated to give an oil 142g XI, a yield of 86.0%;

References:

Weihai Di Su Pharmaceutical Co., Ltd.;Wu, Ronggui;Jiang, Kai;An, Donghua;Cui, Yangyang;Men, Lianbin CN105985257, 2016, A Location in patent:Paragraph 0007; 0014