Domperidone synthesis
- Product Name:Domperidone
- CAS Number:57808-66-9
- Molecular formula:C22H24ClN5O2
- Molecular Weight:425.91
64928-87-6
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57808-66-9
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$26.00/200mg
Yield:57808-66-9 51%
Reaction Conditions:
with sodium bromide;sodium sulfite in nitromethane; for 32 h;Reflux;Solvent;Concentration;
Steps:
3 example 3
0.12 mol of 5-chloro-1- (4-piperidyl) -benzimidazol-2-one (3), 1300 ml of nitromethane, 0.31 mol of sodium sulfite, 1- (3-aminopropyl) (2) 0.15mol, sodium bromide 5g, control the stirring speed 130rpm, reflux 32h, the reaction solution into the mass fraction of 20% sodium chloride solution, reduce the solution temperature to 5 ° C, precipitation The solid was washed with potassium sulfate solution and washed with 80% toluene solution. The activated alumina was dehydrated and recrystallized in 90% (mass fraction) of acetonitrile to give a white solid domperidone (26.07g) with a yield of 51%.
References:
CN105541800,2016,A Location in patent:Paragraph 0014; 0015
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$39.00/1g
53786-28-0
237 suppliers
$47.00/1g
57808-66-9
615 suppliers
$26.00/200mg