ethyl 2,3-diaMinobenzoate synthesis
- Product Name:ethyl 2,3-diaMinobenzoate
- CAS Number:37466-88-9
- Molecular formula:C9H12N2O2
- Molecular Weight:180.2
61063-11-4
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Yield:37466-88-9 99%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethyl acetate at 20; under 2585.81 Torr; for 30 h;
Steps:
7.II
Step II: 2,3-Diamino-benzoic acid ethyl ester (VIII); To a solution of compound (VII) (0.67 g, 0.00319 mol) in AcOEt (30 mL) was added Pd/C (10%) (0.05 g) and the mixture subjected to hydrogenation at 50 psi at room temperature for 30 hrs (TLC monitoring: cyclohexane/AcOEt 2:1). The mixture was filtered and concentrated under reduced pressure to give the compound (VIII) (0.57 g) as a light brown solid, m.p. 56-57°C. Yield: 99%.
References:
WO2008/12852,2008,A1 Location in patent:Page/Page column 25; 38-39
