ChemicalBook CAS DataBase List Ethyl 2-hydroxybenzoate

Ethyl 2-hydroxybenzoate synthesis

14synthesis methods

Product Name:Ethyl 2-hydroxybenzoate
CAS Number:118-61-6
Molecular formula:C9H10O3
Molecular Weight:166.17

Ethyl salicylate is found naturally in currants and strawberries . It is manufactured commercially by the esterification of salicylic acid with ethyl alcohol.

64-17-5 Synthesis

64-17-5
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$10.00/50g

69-72-7 Synthesis

69-72-7
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118-61-6
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$10.00/100g

Yield:118-61-6 97.25%

Reaction Conditions:

with sulfuric acid in water monomer; for 4 h;Reflux;

Steps:

II.B.7.A

To a solution of 2-hydroxybenzoic acid (63) (5.0 g, 36.2 mmol) in anhydrous EtOH (150 ml) was added 98% H₂SO₄(4 ml). The mixture was refluxed for 4 h and concentrated. The residue was extracted with CH₂Cl₂dried over MgSO₄and evaporated. The crude was purified by distillation to give 68 as colorless liquid. (5.85 g, 35.21 mmol). Yield: 97.25%; MS (EI, 70 eV): m/z 166.2 (M⁺); ¹H-NMR (CDCl₃, 200 MHz): δ 1.39 (t, J=7.2 Hz, 3H), 4.37 (q, J=7.2, 7.0 Hz, 2H), 6.81 (t, J=6.6 Hz, 1H), 6.89 (d, J=8.0 Hz, 1H), 7.42 (t, J=7.2 Hz, 1H), 7.82 (dd, J₁=8.0, 1.8 Hz, 1H), 10.83 (s, 1H); ¹³C-NMR (CDCl₃, 50 MHz) δ: 170.20, 161.64, 135.56, 129.89, 119.06, 117.53, 61.40, 14.18; Anal. Calcd for C₉H₁₀O₃: C, 65.05; H, 6.07.