Phenyl salicylate synthesis
- Product Name:Phenyl salicylate
- CAS Number:118-55-8
- Molecular formula:C13H10O3
- Molecular Weight:214.22
100-47-0
357 suppliers
$14.14/25gm:
69-72-7
1194 suppliers
$5.00/10g
118-55-8
402 suppliers
$6.00/25g
Yield:118-55-8 74%
Reaction Conditions:
with thionyl chloride at 75 - 145; for 4 h;Temperature;
Steps:
3 Example 3
In a reaction vessel equipped with a stirrer, a thermometer, a reflux condenser and a dropping funnel, 1.31 mol of benzonitrile and 1.23mol of salicylic acid were added and the solution temperature was raised to 145°C. The stirring speed was controlled to 170 rpm. After 40 min, 0.23mol of thionyl chloride was added and the reaction temperature was maintianed at 138°C. Then the temperature of the solution was reduced to 75°C with the reaction time controlled to 4h. The reaction solution was divided into two layers. The upper layer was separated and added to 200 ml of potassium bromide solution to obtain a solid which was pulverized and washed with 500 ml of a potassium hydrogencarbonate solution having a mass fraction of 70% 6 times, calcium sulfate dehydration, mass fraction of 95% acetonitrile solution was recrystallized, in 197 g of phenyl salicylate, yield 74%.
References:
Chengdu Dongdian Aier Technology Co., Ltd.;Chu, Donghong CN105601511, 2016, A Location in patent:Paragraph 0014; 0015
102-09-0
378 suppliers
$6.00/25g
118-55-8
402 suppliers
$6.00/25g
124-38-9
121 suppliers
$175.00/23402
108-95-2
708 suppliers
$14.00/25g
118-55-8
402 suppliers
$6.00/25g
124-38-9
121 suppliers
$175.00/23402
108-95-2
708 suppliers
$14.00/25g
102-09-0
378 suppliers
$6.00/25g
118-55-8
402 suppliers
$6.00/25g