ChemicalBook CAS DataBase List ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE

ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE synthesis

8synthesis methods

Product Name:ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE
CAS Number:84102-69-2
Molecular formula:C11H9BrO3
Molecular Weight:269.09

10242-11-2
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$23.00/250mg

84102-69-2
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$35.00/250mg

Yield:84102-69-2 93%

Reaction Conditions:

with sulfuric acid in ethanol;

Steps:

5 5C Ethyl 5-bromo-2-benzofurancarboxylate

5C Ethyl 5-bromo-2-benzofurancarboxylate A solution of 5-bromo-2-benzofurancarboxylic acid (5.01 g, 20.8 mmol) in absolute ethanol (150 ml) was added with concentrated sulfuric acid (15 ml) and the mixture was refluxed under stirring for 2 h. After this time, the volatiles were evaporated off under reduced pressure and the resulting residue was neutralized with a sodium bicarbonate saturated solution and extracted with ethyl ether (4*100 ml). The mixture was dried and the solvent was evaporated off under reduced pressure, to obtain 5.19 g of the title compound as a white solid with melting point 58-60° C. (93% yield). ¹ H N.M.R. (300 MHz, CDCl₃) δ ppm: 1.34 (t, 3H); 4.35 (q, 2H); 7.39 (m, 3H); 7.71 (d, 1H).

References:

US5990142,1999,A

105-36-2 Synthesis