
ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE synthesis
- Product Name:ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE
- CAS Number:84102-69-2
- Molecular formula:C11H9BrO3
- Molecular Weight:269.09

105-36-2

1761-61-1

84102-69-2
5-Bromosalicylaldehyde (5 g, 25 mmol, 1.0 eq.) and cesium carbonate (8.2 g, 25 mmol, 1.0 eq.) were dissolved in 80 ml of DMF and stirred well. Subsequently, ethyl bromoacetate (8.3 g, 50 mmol, 2.0 eq.) was slowly added to the reaction system. The reaction mixture was stirred at room temperature for 30 min. After that, the reaction temperature was increased to 120 °C for 2 hours. The reaction progress was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature and poured into ice water and stirred vigorously for 30 minutes. The precipitate was collected by filtration, the filter cake was washed with water and dried to give the yellow powdery solid product ethyl 5-bromobenzofuran-2-carboxylate (4 g, 59.7% yield).

10242-11-2
114 suppliers
$23.00/250mg

84102-69-2
127 suppliers
$35.00/250mg
Yield:84102-69-2 93%
Reaction Conditions:
with sulfuric acid in ethanol;
Steps:
5 5C Ethyl 5-bromo-2-benzofurancarboxylate
5C Ethyl 5-bromo-2-benzofurancarboxylate A solution of 5-bromo-2-benzofurancarboxylic acid (5.01 g, 20.8 mmol) in absolute ethanol (150 ml) was added with concentrated sulfuric acid (15 ml) and the mixture was refluxed under stirring for 2 h. After this time, the volatiles were evaporated off under reduced pressure and the resulting residue was neutralized with a sodium bicarbonate saturated solution and extracted with ethyl ether (4*100 ml). The mixture was dried and the solvent was evaporated off under reduced pressure, to obtain 5.19 g of the title compound as a white solid with melting point 58-60° C. (93% yield). 1 H N.M.R. (300 MHz, CDCl3) δ ppm: 1.34 (t, 3H); 4.35 (q, 2H); 7.39 (m, 3H); 7.71 (d, 1H).
References:
US5990142,1999,A

105-36-2
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1761-61-1
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$5.00/5g

84102-69-2
127 suppliers
$35.00/250mg

51336-47-1
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$244.00/1g

84102-69-2
127 suppliers
$35.00/250mg

685-87-0
260 suppliers
$10.00/5g

78-93-3
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$30.80/500ml

1761-61-1
391 suppliers
$5.00/5g

84102-69-2
127 suppliers
$35.00/250mg

1761-61-1
391 suppliers
$5.00/5g

84102-69-2
127 suppliers
$35.00/250mg