ethyl alpha-oxofuran-2-acetate synthesis
- Product Name:ethyl alpha-oxofuran-2-acetate
- CAS Number:1639-37-8
- Molecular formula:C8H8O4
- Molecular Weight:168.15
Yield:1639-37-8 1519 g
Reaction Conditions:
Stage #1: furanwith sodium in tetrahydrofuran-d8 at 20;Large scale;
Stage #2: oxalic acid diethyl ester in tetrahydrofuran at 20; for 2 h;Large scale;
Steps:
1
700 g of furan (dissolved in 1000 ml of tetrahydrofuran) was slowly added dropwise to 230 g of metallic sodium sand(The reaction process can also be added to the electron transfer agent,Such as α-methylstyrene, etc.),Room temperature reaction 2-4 hours,While stirring, 1500 g of diethyl oxalate was added dropwise,Room temperature reaction for 2 hours,filter,The reaction solution was neutralized to pH = 6.5-7.5,Extracted twice with 500 ml of ethyl acetate,Take the organic layer,The solvent was evaporated to give 1519 g of product,
References:
CN106554336,2017,A Location in patent:Paragraph 0057-0059
19377-72-1
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