ETHYL ISOCYANIDE synthesis
- Product Name:ETHYL ISOCYANIDE
- CAS Number:624-79-3
- Molecular formula:C3H5N
- Molecular Weight:55.08
To a three-necked flask equipped with a condenser and ground glass stirrer (or Hershberg stirrer) is added 116 gm (0.75 mole) of ethyl iodide and 100 gm (0.75 mole) of silver cyanide. The mixture is refluxed for 2 hr, the stirrer blade raised, the mixture cooled, filtered (see Note a), the solid washed with ether, dried, and 260 gm of a 50% solution of potassium cyanide (2.0 moles) added. The reaction mixture is distilled to afford a mixture of isonitrile and water (see Note b). The crude isonitrile 49.5- 52.3 gm (90-95%) is separated after being salted out of the water. The isonitrile is washed twice with 24-ml portions of ice-cold saturated sodium chloride solution, dried over magnesium sulfate, and fractionally distilled, to afford 25.9-30.3 gm (47-55%), b.p. 77-79°C (760 mm Hg).
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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Yield: 84% ， 40 % Spectr. ， 44%
Reaction Conditions:
with triethyloxonium fluoroborate in dichloromethaneProduct distribution;Ambient temperature;
References:
Kantlehner, Willi;Greiner, Ulrich [Liebigs Annalen der Chemie,1990,# 10,p. 965 - 973]
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624-79-3
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624-79-3
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624-79-3
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