Etretinate synthesis
- Product Name:Etretinate
- CAS Number:54350-48-0
- Molecular formula:C23H30O3
- Molecular Weight:354.48
697-82-5
345 suppliers
$7.00/10g
54350-48-0
147 suppliers
$25.00/10mg
Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 12 h / 25 °C
2.1: trichlorophosphate / 0.25 h / 10 - 20 °C
2.2: 6 h / 10 - 110 °C
3.1: sodium hydroxide / water / 7.5 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
4.2: 6 h / 0 °C / Reflux
5.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 24 h / 0 - 20 °C
6.1: sodium carbonate; manganese(IV) oxide / dichloromethane / 48 h / 20 °C
7.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere
7.2: 1 h / -78 - 0 °C
References:
Kang, Yan-Fei;Yan, Wen-Jing;Zhou, Ting-Wen;Dai, Fang;Li, Xiu-Zhuang;Bao, Xia-Zhen;Du, Yu-Ting;Yuan, Cui-Hong;Wang, Hai-Bo;Ren, Xiao-Rong;Liu, Qiang;Jin, Xiao-Ling;Zhou, Bo;Zhang, Jie [Chemistry - A European Journal,2014,vol. 20,# 29,p. 8904 - 8908]
41891-54-7
78 suppliers
$95.00/1g
69877-38-9
41 suppliers
$156.00/100mg
54350-48-0
147 suppliers
$25.00/10mg
20469-61-8
107 suppliers
$19.00/5g
54350-48-0
147 suppliers
$25.00/10mg
62054-49-3
89 suppliers
$50.00/10g
54350-48-0
147 suppliers
$25.00/10mg
3230-69-1
112 suppliers
$58.10/5g
54350-48-0
147 suppliers
$25.00/10mg