ChemicalBook CAS DataBase List Olverembatinib

Olverembatinib synthesis

4synthesis methods

Product Name:Olverembatinib
CAS Number:1257628-77-5
Molecular formula:C29H27F3N6O
Molecular Weight:532.56

In a recent patent, the synthesis of olverembatinib began with a Sonogashira coupling reaction of commercially available alkyne 24.1 with pyridinium bromide 24.2 to afford ester 24.3 in 98% yield. The N-Boc group of carbonate 24.3 was cleaved by refluxing in a mixture of MeOH and water to afford pyrazole 24.4 in 91% yield. Finally, potassium tert-butoxide-mediated amide formation with aniline 24.5 afforded olverembatinib (24) in 88% yield.

694499-26-8 Synthesis

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

694499-26-8
231 suppliers
$9.00/250mg

1257628-77-5
104 suppliers
$25.00/1mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 3 h / -20 - 20 °C / Inert atmosphere
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 20 h / 20 - 100 °C / Sealed tube; Inert atmosphere

References:

Ren, Xiaomei;Pan, Xiaofen;Zhang, Zhang;Wang, Deping;Lu, Xiaoyun;Li, Yupeng;Wen, Donghai;Long, Huoyou;Luo, Jinfeng;Feng, Yubing;Zhuang, Xiaoxi;Zhang, Fengxiang;Liu, Jianqi;Leng, Fang;Lang, Xingfen;Bai, Yang;She, Miaoqin;Tu, Zhengchao;Pan, Jingxuan;Ding, Ke [Journal of Medicinal Chemistry,2013,vol. 56,# 3,p. 879 - 894]

90347-66-3 Synthesis

90347-66-3
217 suppliers
$10.00/5g

1257628-77-5
104 suppliers
$25.00/1mg

References

875781-17-2 Synthesis

875781-17-2
258 suppliers
$7.00/250mg

1257628-77-5
104 suppliers
$25.00/1mg

References

1H-Pyrazolo[3,4-b]pyridine, 5-[2-(trimethylsilyl)ethynyl]-

1207351-08-3
0 suppliers
inquiry

1257628-77-5
104 suppliers
$25.00/1mg

References

Olverembatinib Related Search:

Lenvatinib Cabozantinib Axitinib

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