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ChemicalBook CAS DataBase List Haloxyfop-P
95977-29-0

Haloxyfop-P synthesis

2synthesis methods
Haloxyfop-P tends to be used and produced as the methyl variant. The commercial production of haloxyfop-P-methyl involves a multi-step synthetic process designed to yield the biologically active R-enantiomer with high optical purity. It begins with the preparation of a substituted hydroquinone, which undergoes etherification with a chiral alkylating agent, typically (R)-2-bromopropionic acid methyl ester, to introduce the stereocentre. This intermediate is then reacted with a halogenated pyridine derivative, such as 3-chloro-2-bromo-5-trifluoromethylpyridine, under controlled conditions to form the key pyridyloxy linkage. The resulting compound is purified and esterified to produce haloxyfop-P-methyl.

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