indan-1-carbonitrile synthesis
- Product Name:indan-1-carbonitrile
- CAS Number:26452-97-1
- Molecular formula:C10H9N
- Molecular Weight:143.19
29872-81-9
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Yield:26452-97-1 95%
Reaction Conditions:
with hydrogen;5%-palladium/activated carbon in ethanol;
Steps:
4 Example 4; 1-indanecarbonitrile
A suspension of 5% Pd on carbon in a solution of 1 H-INDENE-3-CARBONITRILE IN ETOH (200MUT) was placed under an atmosphere of hydrogen with vigorous stirring overnight. After removal of excess hydrogen from the reaction the solution as filtered through celite and concentrated to an oil. The resulting oil was re-dissolved in EtOH and filtered a second time to remove the remaining carbon and catalyst. Evaporation of solvent afforded 12.0108g of 1-INDANECARBONITRILE (95% yield) as an oil. 1 H NMR (400 MHz, DMSO-D6) 8 ppm 2.2 (m, 1 H) 2.5 (m, 1 H) 2.9 (m, 1 H) 3.0 (m, 1 H) 4.4 (t, J=8.0 Hz, 1 H) 7.2 (m, 2 H) 7.3 (m, 1 H) 7.4 (m, J=7.7, 4.9 Hz, 1 H).
References:
WO2004/55012,2004,A1 Location in patent:Page 53
106783-39-5
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26452-97-1
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