ChemicalBook CAS DataBase List L-Proline

L-Proline synthesis

3synthesis methods

Product Name:L-Proline
CAS Number:147-85-3
Molecular formula:C5H9NO2
Molecular Weight:115.13

Synthesis of L-proline: Using glutamic acid as a raw material, it is esterified with absolute ethanol under the catalysis of sulfuric acid, and triethanolamine is added to free the aminosulfate to obtain glutamic acid-δ-ethyl ester. The glutamic acid-δ-ethyl ester is then reduced with a metal reducing agent potassium borohydride to obtain crude proline, which is finally separated and purified to obtain crude L-proline.

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147-85-3
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Yield:147-85-3 100%

Reaction Conditions:

with hydrogen;palladium on activated charcoal in ethyl acetate at 80; for 0.0833333 h;Microwave irradiation;

Steps:

A number of hydrogenation reactions were conducted using the present apparatus and method. Several of these reactions, along with their reaction conditions and yields, are listed below. Unless otherwise noted, each reaction proceeded with a stoichiometric amount of hydrogen with respect to the reactant to be hydrogenated and 1% catalyst loading.As used in the drawings, the abbreviation Pd/C refers to a palladium metal catalyst on a carbon support. The abbreviation EtOH refers to ethyl alcohol and the abbreviation EtOAc refers to ethyl acetate. The abbreviation μλ refers to the application of microwaves. Simultaneous cooling was carried out using the PowerMAX single mode capacity microwave instrument available from the assignee herein, CEM Corporation of Matthews, N.C., USA.

References:

US2007/209924,2007,A1 Location in patent:Page/Page column 7

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147-85-3
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References

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147-85-3
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References

L-Proline Related Search:

L-Isoleucine L-Glutamine L(+)-Arginine L-Glutamic acid L-Prolinamide L-Citrulline L-Methionine L-Alanine Enalaprilat Enalapril diketopiperazine