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L-Proline

L-Proline
L-Proline structure
CAS No.
147-85-3
Chemical Name:
L-Proline
Synonyms
PRO;L-PRO;-ProL;cb1707;ccc(u);L-Pro-OH;H-PRO-OH;L-Pronna;l-prolin;L-Poline
CBNumber:
CB6118196
Molecular Formula:
C5H9NO2
Formula Weight:
115.13
MOL File:
147-85-3.mol

L-Proline Properties

Melting point:
228 °C (dec.) (lit.)
Boiling point:
215.41°C (rough estimate)
alpha 
-85.5 º (c=4, H2O)
Density 
1.35
refractive index 
-85 ° (C=4, H2O)
FEMA 
3319 | L-PROLINE
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
pka
1.95, 10.64(at 25℃)
color 
White
PH
6.0-7.0 (25℃, 1M in H2O)
optical activity
[α]20/D 85.0±1.0°, c = 5% in H2O
Water Solubility 
soluble
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number
1425
Merck 
14,7780
BRN 
80810
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
ONIBWKKTOPOVIA-UHFFFAOYSA-N
Substances Added to Food (formerly EAFUS)
L-PROLINE
FDA 21 CFR
172.320
CAS DataBase Reference
147-85-3(CAS DataBase Reference)
NIST Chemistry Reference
Proline(147-85-3)
EPA Substance Registry System
L-Proline (147-85-3)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  24/25-36/37/39-26
WGK Germany  3
RTECS  TW3584000
3-10
TSCA  Yes
HS Code  29339990
Toxicity LD50 orally in Rabbit: > 5110 mg/kg

L-Proline price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.16019 (S)-(-)-Proline for synthesis 147-85-3 25 g $28.77 2021-03-22 Buy
Sigma-Aldrich 81709 L-Proline BioUltra, ≥99.5% (NT) 147-85-3 10g $57.9 2020-08-18 Buy
Sigma-Aldrich W331902 L-Proline 99%, FCC, FG 147-85-3 100 g $65 2021-03-22 Buy
Sigma-Aldrich 8.16019 (S)-(-)-Proline for synthesis 147-85-3 100 g $77.51 2021-03-22 Buy
Sigma-Aldrich W331902 L-Proline 99%, FCC, FG 147-85-3 1 kg $135 2021-03-22 Buy

L-Proline Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Chemical Properties

L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.

Occurrence

Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.

Uses

amino acid, nutrient

Uses

L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.

Preparation

From α-piperidone; from cyclopentantone; from l-glutamic acid.

Purification Methods

A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]

L-Proline Preparation Products And Raw materials

Raw materials

Preparation Products


L-Proline Suppliers

Global( 761)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
SHANDONG ZHI SHANG CHEMICAL CO.LTD
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View Lastest Price from L-Proline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 L-Proline
147-85-3
US $30.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-12-01 L-Proline
147-85-3
US $10.00 / KG 1KG 99% 5000kg Hebei Crovell Biotech Co Ltd
2021-11-30 L-Proline
147-85-3
US $18.50 / KG 100KG 98% 1-200mt Baoji Guokang Bio-Technology Co., Ltd.

L-Proline Spectrum


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