methyl 3-((diethoxyphosphoryl)methyl)benzoate synthesis

10synthesis methods

Product Name:methyl 3-((diethoxyphosphoryl)methyl)benzoate
CAS Number:96534-02-0
Molecular formula:C13H19O5P
Molecular Weight:286.26

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methyl 3-((diethoxyphosphoryl)methyl)benzoate

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Yield:96534-02-0 100%

Reaction Conditions:

at 185; for 4 h;

Steps:

5

Methyl-3-bromomethyl-benzoate (14 g, 61 mmol) in triethylphosphite (12 mL, 70 mmol) was stirred at 185° C. for 4 hours. Excess triethylphosphite was removed by vacuum distillation (150 mT, 145° C.) and the resulting oil was used without further purification. Yield=17.5 g. (100%) of diethyl (3-methoxycarbonyl) benzyl phosphonate.

References:

US6639078,2003,B1 Location in patent:Page/Page column 15-16

78-40-0 Synthesis