Methyl-3-trifluoromethylphenoxyacetate, 98 % synthesis
- Product Name:Methyl-3-trifluoromethylphenoxyacetate, 98 %
- CAS Number:588-26-1
- Molecular formula:C10H9F3O3
- Molecular Weight:234.17
Yield:588-26-1 99%
Reaction Conditions:
with potassium carbonate in butanone; for 3 h;Heating / reflux;
Steps:
A.4
A mixture of 3-trifluoromethyl-phenol (5.000 g; 30.843 mmol), potassium carbonate (5.328 g; 38.554 mmol), and methyl bromoacetate (3.54 ml; 38.554 mmol) in butanone (210 ml) was heated at reflux for 3h. Filtration, concentration to dryness under reduced pressure, and purification by FC (heptane / EA, 4 / 1 ) afforded (3-trifluoromethyl-phenoxy)-acetic acid methyl ester as a pale yellow oil (7.220 g; 99%). LC-MS: tR = 0.95 min.; [M+H]+: no ionisation.
References:
WO2008/78291,2008,A1 Location in patent:Page/Page column 57
98-17-9
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