methyl (R)-thiazolidine-4-carboxylate synthesis
- Product Name:methyl (R)-thiazolidine-4-carboxylate
- CAS Number:42258-90-2
- Molecular formula:C5H9NO2S
- Molecular Weight:147.2
Yield:42258-90-2 89.1%
Reaction Conditions:
with hydrogenchloride at 30; for 14 h;Temperature;
Steps:
1.2; 2.2; 3.2; 4.2; 5.2; 6.2 2. Synthesis of thiazolidine-4-carboxylic acid methyl ester
In a dry round bottom flask, 10 g (0.075 mol) of thiazolidine-4-carboxylic acid was added.100 mL (2.47 mol) of methanol was passed through a dry HCl gas.Reaction at 30 ° C for 14 h,Add 200 mL of diethyl ether, precipitate with white flaky crystals, and dry by suction filtration to obtain the thiazolidine-4-carboxylic acid methyl ester hydrochloride.Add 30% NaOH solution and neutralize pH=6-7, and add 100 mL of ethyl acetate for extraction.The ethyl acetate of thiazolidine-4-carboxylate 9.849 was obtained by rotary evaporation to give a yield of 89.1%.
References:
CN109574953,2019,A Location in patent:Paragraph 0021; 0024-0025; 0031; 0034-0035; 0041; 0044-0045
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