METHYL 5-METHYLNICOTINATE synthesis
- Product Name:METHYL 5-METHYLNICOTINATE
- CAS Number:29681-45-6
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
67-56-1
776 suppliers
$7.29/5ml-f
3222-49-9
390 suppliers
$6.00/5g
29681-45-6
202 suppliers
$8.00/1g
Yield:29681-45-6 98.2%
Reaction Conditions:
with thionyl chloride at 20; for 4 h;Inert atmosphere;Reflux;Concentration;
Steps:
1 Example 1
Synthesis of Compound (3):
In a 1000mL four-necked bottle,Add compound (2) 5-methylnicotinic acid (100.0 g, 0.73 mol)And 500mL of methanol,Under the protection of nitrogen,Thionyl chloride (110 mL, 1.5 mol) was added dropwise.The temperature is maintained at 20 to 25 °C.After the addition was completed, the mixture was heated to reflux for 4 h.Evaporate the methanol under reduced pressure, add 200 mL of ice water, and neutralize to a weak alkaline (pH 7-10) with saturated sodium carbonate solution.The mixture was extracted with EtOAc.A white solid (108.2 g, 98.2%) was obtained.
References:
Shanghai Applied Technology College;Lu Yan;Wang Jin;Guo Jianyu;Huang Minfei;Xiong Lei CN104163786, 2016, B Location in patent:Paragraph 0035; 0036; 0037; 0038; 0054
591-22-0
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$11.19/25ML
29681-45-6
202 suppliers
$8.00/1g
42972-46-3
40 suppliers
$81.00/100mg
29681-45-6
202 suppliers
$8.00/1g
67-56-1
776 suppliers
$7.29/5ml-f
42885-14-3
98 suppliers
$17.00/250mg
29681-45-6
202 suppliers
$8.00/1g