N-(2-Cyanoethyl) GlycineEthyl Ester synthesis
- Product Name:N-(2-Cyanoethyl) GlycineEthyl Ester
- CAS Number:44981-94-4
- Molecular formula:C7H12N2O2
- Molecular Weight:156.18
Yield:44981-94-4 89.3%
Reaction Conditions:
with potassium hydroxide in water at 20;Cooling with ice bath;
Steps:
EXAMPLES ExperimentalPreparation of 1-1To a mixture of 139.6 g (1 mole) of glycine ethylester HCl and 131.76 ml (2 mole) of acrylonitrile in 80 ml of water in an ice bath was treated drop wise with a solution of 516.11 g (1 mole) of KOH in 200 ml of water. After the addition completed, stirring continued at ice bath temp for two hrs and then stirred at ambient temperature over night. The pH of the reaction mixture adjusted to 7-8 with 1 N NaOH solution and the mixture extracted with CH2Cl2 (3×). The organic layer washed with water and brine, then dried and the solvent removed in vacuum to give 140 g of 1-1 as a light yellow oil.
References:
US2011/71179,2011,A1 Location in patent:Page/Page column 16; 17
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