N-(4-Methoxybenzyl)-4-nitrobenzenesulfonaMide, 97% synthesis
- Product Name:N-(4-Methoxybenzyl)-4-nitrobenzenesulfonaMide, 97%
- CAS Number:171414-17-8
- Molecular formula:C14H14N2O5S
- Molecular Weight:322.34
2393-23-9
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171414-17-8
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Yield:171414-17-8 95%
Reaction Conditions:
with 4-methyl-morpholine in dichloromethane at 0 - 20;
Steps:
6.8. General procedure 3: reaction of amines with 4-nitrobenzenesulfonylchloride30
General procedure: The amine is dissolved in dichloromethane, cooled to 0 °C and N-methylmorpholine (0.24 mL/mmol amine) is added. An equimolar amount of sulfonylchloride, also dissolved in dichloromethane, is added dropwise to the solution. After stirring over night at room temperature, the solution is washed three times with 2 M hydrochloric acid, once with a saturated solution of NaHCO3 and once with brine. The organic layer is dried over MgSO4. To obtain the crude product, the solvent is removed in vacuo. The crude product may be purified by flash column chromatography.
References:
Bissinger, Elisabeth-Maria;Heinke, Ralf;Spannhoff, Astrid;Eberlin, Adrien;Metzger, Eric;Cura, Vincent;Hassenboehler, Pierre;Cavarelli, Jean;Schuele, Roland;Bedford, Mark T.;Sippl, Wolfgang;Jung, Manfred [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 12,p. 3717 - 3731] Location in patent:experimental part
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840529-62-6
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171414-17-8
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6325-93-5
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171414-17-8
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6325-93-5
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123-11-5
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171414-17-8
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32337-46-5
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2393-23-9
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3526-43-0
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138-42-1
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171414-17-8
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108-95-2
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