N-(4-Methoxybenzyl)-4-nitrobenzenesulfonaMide, 97% synthesis
- Product Name:N-(4-Methoxybenzyl)-4-nitrobenzenesulfonaMide, 97%
- CAS Number:171414-17-8
- Molecular formula:C14H14N2O5S
- Molecular Weight:322.34
2393-23-9
485 suppliers
$20.00/25g
98-74-8
171 suppliers
$10.00/5g
171414-17-8
7 suppliers
$63.70/100mg
Yield:171414-17-8 95%
Reaction Conditions:
with 4-methyl-morpholine in dichloromethane at 0 - 20;
Steps:
6.8. General procedure 3: reaction of amines with 4-nitrobenzenesulfonylchloride30
General procedure: The amine is dissolved in dichloromethane, cooled to 0 °C and N-methylmorpholine (0.24 mL/mmol amine) is added. An equimolar amount of sulfonylchloride, also dissolved in dichloromethane, is added dropwise to the solution. After stirring over night at room temperature, the solution is washed three times with 2 M hydrochloric acid, once with a saturated solution of NaHCO3 and once with brine. The organic layer is dried over MgSO4. To obtain the crude product, the solvent is removed in vacuo. The crude product may be purified by flash column chromatography.
References:
Bissinger, Elisabeth-Maria;Heinke, Ralf;Spannhoff, Astrid;Eberlin, Adrien;Metzger, Eric;Cura, Vincent;Hassenboehler, Pierre;Cavarelli, Jean;Schuele, Roland;Bedford, Mark T.;Sippl, Wolfgang;Jung, Manfred [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 12,p. 3717 - 3731] Location in patent:experimental part
![Benzenesulfonamide, N-[(4-methoxyphenyl)methylene]-4-nitro-](/CAS/20210305/GIF/840529-62-6.gif)
840529-62-6
0 suppliers
inquiry
171414-17-8
7 suppliers
$63.70/100mg
6325-93-5
138 suppliers
$10.00/1g
171414-17-8
7 suppliers
$63.70/100mg
6325-93-5
138 suppliers
$10.00/1g
123-11-5
878 suppliers
$10.00/10g
171414-17-8
7 suppliers
$63.70/100mg
32337-46-5
1 suppliers
inquiry
2393-23-9
485 suppliers
$20.00/25g
3526-43-0
77 suppliers
$28.60/250mg
138-42-1
5 suppliers
$23.00/1g
171414-17-8
7 suppliers
$63.70/100mg
108-95-2
764 suppliers
$14.00/25g