N-Benzyl-9-(tetrahydro-2H-pyran-2-yl)adenine synthesis
- Product Name:N-Benzyl-9-(tetrahydro-2H-pyran-2-yl)adenine
- CAS Number:2312-73-4
- Molecular formula:C17H19N5O
- Molecular Weight:309.37
Figure Preparation of N-Benzyl-9-(tetrahydro-2H-pyran-2-yl)adenine
7306-68-5
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2312-73-4
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Yield:2312-73-4 66%
Reaction Conditions:
with triethylamine in isopropyl alcohol at 40; for 8 h;
Steps:
2 6-Benzylamino-9-( tetrahydropyran-2-yl)-9H-purine
6-Chloro-9-(tetrahydropyran-2-yl)-9H-purine (Ex 1.) (2.52 g, 10.6 mmol) was dissolved in 2- propanol (13.5 ml). Benzylamine (1.4 ml, 12.8 mmol) and triethylamine (1.5 ml, 10.5 mmol) were added. The solution was stirred and heated at 40 °C for 8 h. The mixture was evaporated to dryness, dissolved in 20 ml of ethyl acetate and extracted with 15 ml of water twice. Ethyl acetate layer was dried with Na2S04 and evaporated. The crude product crystallizes after drying in desiccator with P205 to give (2.14 g, 66 %). white crystals, m. p. : 124-127 °C. MS ESI+ (CV 10) m/z (rel. %): 310 [M+H]+ (100); (CV 40) m/z (rel. %): 226 [Ci2H„N5+H]+ (100), 310 [M+H]+
References:
USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.;ZAHAJSKA, Lenka;NISLER, Jaroslav;KADLECOVA, Alena;ZATLOUKAL, Marek;GRUZ, Jiri;VOLLER, Jiri;DOLEZAL, Karel;STRNAD, Miroslav WO2016/95880, 2016, A1 Location in patent:Page/Page column 19
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1214-39-7
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2312-73-4
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2312-73-4
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2312-73-4
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$454.00/250mg
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2312-73-4
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$454.00/250mg