N-BOC-5-HYDROXYINDOLINE synthesis
- Product Name:N-BOC-5-HYDROXYINDOLINE
- CAS Number:170147-76-9
- Molecular formula:C13H17NO3
- Molecular Weight:235.28
273408-46-1
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170147-76-9
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Yield: 95%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 2 h;
Steps:
3.2 tert-butyl 5-hydroxyindoline-1-carboxylate
Compound 5- (benzyloxy) indoline-1-carboxylic acid tert-butyl ester 3a (2.42 g, 7.44 mmol) was dissolved in methanol (80 mL),Then 10% palladium on carbon (1.2 g) was added and stirred at room temperature under a hydrogen atmosphere for 2 hours.After the reaction was completed, the filtrate was filtered, and the solvent was removed under reduced pressure.The target product 5-hydroxyindoleline-1-carboxylic acid tert-butyl ester 3b (1.65 g, gray solid) was obtained,Yield: 95%.
References:
Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.;Bu Gonggaofamingren CN110483482, 2019, A Location in patent:Paragraph 0112; 0115; 0121-0125
170147-29-2
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170147-76-9
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24424-99-5
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172078-33-0
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170147-76-9
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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170147-76-9
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$133.00/250mg
1215-59-4
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170147-76-9
68 suppliers
$133.00/250mg