N-Boc-piperidine-2-methanol synthesis
- Product Name:N-Boc-piperidine-2-methanol
- CAS Number:157634-00-9
- Molecular formula:C11H21NO3
- Molecular Weight:215.29
24424-99-5
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3433-37-2
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157634-00-9
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Yield:157634-00-9 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 16 h;
Steps:
INTERMEDIATE 28 (METHOD Z); ferf-Butyl 2-(hydroxymethyl*)piperidine- 1 -carboxylate; To a stirred solution of 2-piperidinemethanol (3.0 g, 25.60 mmol) in DCM (100 mL) was added triethylamine (14.5 mL, 91.08 mmol) and then di-tert-butyl dicarbonate (7.2 g, 31.0 mmol) portionwise. The reaction mixture was stirred at r.t. for 16 h. Water (70 mL) was added and the layers were separated. The organic layer was washed with water (2 x 50 mL), dried (Na2SO4), filtered and concentrated in vacuo to give the title compound (6.0 g, quantitative) as a pale brown oil that was used without further purification. δH (CDCl3) 4.42-4.22 (IH, m), 4.05-3.91 (IH, m), 3.89-3.77 (IH, m), 3.71- 3.53 (IH, m), 2.97-2.81 (IH, m), 2.32-2.08 (IH, m), 1.90 (IH, s), 1.77-1.57 (3H, m), 1.54 (IH, s), 1.52-1.38 (1OH, m).
References:
WO2007/141504,2007,A1 Location in patent:Page/Page column 57
98303-20-9
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157634-00-9
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157634-00-9
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13139-12-3
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3433-37-2
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157634-00-9
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157634-00-9
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