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ChemicalBook CAS DataBase List N-(cyclohexylmethyl)cyclohexanamine
87364-66-7

N-(cyclohexylmethyl)cyclohexanamine synthesis

11synthesis methods
-

Yield:87364-66-7 68 %Chromat.

Reaction Conditions:

with hydrogen at 40; under 3750.38 Torr; for 24 h;Autoclave;

Steps:

Generalprocedure for catalytic reductive amination of phenol

General procedure: Reductiveamination of phenols was carried out in a 10-mL autoclave reactor equipped witha glass tube. In a typical experiment, the reactor was charged with 1 mmol ofsubstrate, 1.2-3 mmol of ammonia (28 % aqueous ammonia)/amines and catalyst (2mol %). For the reactions of CHP, 1 mol% (calculated on metal amount) of 5 wt%Rh-PVP-5 wt% Sn/TiO2 catalyst was used. The reactor was purged,pressurized to 5-20 bar of hydrogen and heated to 40-100 °C. The conversion andyield of product were obtained by GC analysis using dodocane an internalstandard. The products were confirmed by GC-MS analysis.

References:

Chaudhari, Chandan;Nagaoka, Katsutoshi;Nishida, Yoshihide;Rumi, Saeki;Sato, Katsutoshi;Shiraishi, Masaya [Chemistry Letters,2022,vol. 51,# 1,p. 81 - 84] Location in patent:supporting information