ChemicalBook CAS DataBase List N-Ethylbenzylamine

N-Ethylbenzylamine synthesis

13synthesis methods

Product Name:N-Ethylbenzylamine
CAS Number:14321-27-8
Molecular formula:C9H13N
Molecular Weight:135.21

100-52-7 Synthesis

100-52-7
951 suppliers
$20.37/250g

75-04-7
369 suppliers
$10.00/20mg

14321-27-8
212 suppliers
$7.00/5g

Yield:14321-27-8 94.9%

Reaction Conditions:

Stage #1: benzyl aldehyde;ethylamine in methanol at 20;
Stage #2: with sodium tetrahydridoborate in methanol; for 6 h;

Steps:

General procedure for the preparation of compounds 7a-d.

General procedure: To a mixture of benzaldehydes (10 mmol) in methanol (20 mL), the methylamine or ethylamine(10 mmol) was added. The reaction mixturewas stirred at room temperature for 3-4 h, and then sodium borohydride (5.0mmol) was added in batches and the mixture was further stirred for anotherperiod of 6 h. The reaction was then quenched by the addition of water (10 mL),and washed with diethyl ether (20 mL× 3). The combined organic phases werewashed with saturated aqueous NaCl (30 mL), dried over Na₂SO₄,and filtered. The solvent was evaporated to dryness under reduced pressure. The residue was purified on a silica gel chromatography usingmixtures of CH₂Cl₂/CH₃OH as eluent to obtainthe light yellow oil 7a-d.

References:

Pan, Wanli;Hu, Ke;Bai, Ping;Yu, Lintao;Ma, Qinge;Li, Tao;Zhang, Xu;Chen, Changzhong;Peng, Kelin;Liu, Wenmin;Sang, Zhipei [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 10,p. 2539 - 2543] Location in patent:supporting information

614-17-5 Synthesis