N-Methyl-N-(trimethylsilyl)trifluoroacetamide synthesis

Yield:-

Reaction Conditions:

in benzene at 80; for 3 h;Temperature;

Steps:

2 Synthesis of MSTFA
254 g (2.0 moles) of N-methyltrifluoroacetamide, 528 g (2.6 moles) of N, O-bis (trimethylsilyl) acetamide (N, O -bis (trimethylsilyl) acetamide) (BSA),And 400 ml of benzene. The reaction mixture was heated to 80 DEG C and stirred for 3 hours. After the reaction mixture was cooled to room temperature and the solvent was evaporated in the after-air,MSTFA was synthesized by fractional distillation under reduced pressure of 52 ~ 53 DEG C and 40 mmHg.

References:

SAMSUNG FINE CHEMICALS CO., LTD.;KOH, JOO HWAN;JEONG, KI YOUNG;SEO, JIN AH;PARK, MIN JE;SHIN, YOUNG HOON;JO, SUNG NIM KR2015/79076, 2015, A Location in patent:Paragraph 0021-0022; 0058-0059

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