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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
20173-72-2

N,N,4-TRIMETHYL-2-PYRIDINAMINE synthesis

4synthesis methods
4-Methylpyridin-2-amine

695-34-1
544 suppliers
$5.00/10g

64-19-7 Synthesis
Acetic acid

64-19-7
1585 suppliers
$10.00/25ML

N,N,4-TRIMETHYL-2-PYRIDINAMINE

20173-72-2
17 suppliers
$45.00/50mg

-

Yield:20173-72-2 88%

Reaction Conditions:

with formaldehyd;sodium cyanoborohydride in water;acetonitrile at 0 - 20; for 168 h;

Steps:

1.1A

EXAMPLE 1; SYNTHESIS OF REAGENT [5-(7-CHLORO-2,5-DIMETHYL-PYRAZOLO[1,5-A]PYRIMΓDIN-3-YL)-4-METHYL-PYRIDIN-2- YL] -DIMETHYL- AMINE; EPO ; Step IA; To a mixture of 2-amino-4-picoline (33 g), NaBH3CN (57 g), formaldehyde (37% aq. solution, 240 mL) in acetonitrile (1 L) and water (200 mL) was added dropwise acetic acid (60 mL) at 0 °C in 2 hr. The resultant solution was stirred at RT for 7 days and then concentrated in vacuo. The residue was basified with solid NaOH to pH 10 and extracted with hexanes (3x 700 mL). The combined extract was washed with IN aq. NaOH and brine, dried over Na2SO4 and evaporated in vacuo to give 2-dimethylamino-4- methylpyridine as a colorless oil (Cmpd Ia, 36 g, 88%). 1H NMR (CDCl3): 2.26 (s, 3H), 3.07 (s, 6H), 6.33 (s, IH), 6.40 (d, IH), 8.02 (d, IH); MS (CI) m/e 137 (MH+).

References:

WO2006/44958,2006,A1 Location in patent:Page/Page column 38-39

4-Methylpyridin-2-amine

695-34-1
544 suppliers
$5.00/10g

Iodomethane

74-88-4
353 suppliers
$15.00/10g

N,N,4-TRIMETHYL-2-PYRIDINAMINE

20173-72-2
17 suppliers
$45.00/50mg

References
4-Methylpyridin-2-amine

695-34-1
544 suppliers
$5.00/10g

50-00-0 Synthesis
Formaldehyde

50-00-0
892 suppliers
$10.00/25g

N,N,4-TRIMETHYL-2-PYRIDINAMINE

20173-72-2
17 suppliers
$45.00/50mg

References
4-Methylpyridin-2-amine

695-34-1
544 suppliers
$5.00/10g

N,N,4-TRIMETHYL-2-PYRIDINAMINE

20173-72-2
17 suppliers
$45.00/50mg

References