ChemicalBook CAS DataBase List N-phenylpiperidin-4-amine

N-phenylpiperidin-4-amine synthesis

7synthesis methods

Product Name:N-phenylpiperidin-4-amine
CAS Number:23056-29-3
Molecular formula:C11H16N2
Molecular Weight:176.26

125541-22-2 Synthesis

125541-22-2
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$31.00/1g

23056-29-3
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$217.00/5g

Yield:23056-29-3 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

Reagents and conditions: (a) NaBH(OAc)₃, AcOH, aniline, DCE, overnight, rt, (yield 84%); (b) TFA, DCM, lh, rt, quant; (c) toluene, 2h, rt, (general yields 5- 23%). In Scheme 8, the reductive amination of aniline with 1 -boc-4-piperidone followed by deprotection in acidic condition afforded compound 6 which was reacted with appropriate isocyanates or isothiocyanates to produce the 4- anilinopiperidine series 7a-g.

References:

ROBERTS, Edward;MITTAPALLI, Gopi Kumar;VELLUCCI, Danielle;YANG, Jun;GUERRERO, Miguel;URBANO, Mariangela;ROSEN, Hugh WO2014/116684, 2014, A1 Location in patent:Page/Page column 251

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