ChemicalBook CAS DataBase List Olanzapine

Olanzapine synthesis

7synthesis methods

Product Name:Olanzapine
CAS Number:132539-06-1
Molecular formula:C17H20N4S
Molecular Weight:312.43

161696-76-0
104 suppliers
$60.00/5mg

74-88-4
339 suppliers
$15.00/10g

132539-06-1
479 suppliers
$28.00/25mg

Yield:132539-06-1 99%

Reaction Conditions:

with potassium tert-butylate in tetrahydrofuran at 0; for 2 h;Product distribution / selectivity;

Steps:

7

Example 7; 10 g of N-desmethylolanzapine (0.034 mol) is dissolved in 240 mi tetrahydrofuran and while stirring cooled to 0 °C. 4.48 g of potassium t-butoxid and 5 ml (0.080 mol) of methyl iodide are added. The reaction mixture is stirred for 2 hours at 0 °C, the end of the reaction is determined by HPLC. After completing the reaction 200 ml of demineralised water is added and tetrahydrofuran is evaporated, the title compound is crystallised as yellow crystals. The precipitate is filtered off and washed with water to give 10.4 g of crude olanzapine (yield : 99 %).

References:

WO2005/90359,2005,A2 Location in patent:Page/Page column 21