Plerixafor Impurity 7 synthesis
- Product Name:Plerixafor Impurity 7
- CAS Number:117152-72-4
- Molecular formula:C24H36N4O4S2
- Molecular Weight:508.7
Yield:117152-72-4 81.39%
Reaction Conditions:
with triethylamine in dichloromethane at 30; for 10 h;Cooling with ice;Reagent/catalyst;
Steps:
2.1
(1) 30.0 g of 1,4,8,11-tetraazacyclotetradecane was dissolved in 1 L of dry methylene chloride, and 52 mL of triethylamine and 48.5 g of p-toluenesulfonyl chloride were added under an ice bath to obtain a colorless solution. The solution was reacted at 30°C for 10 hours.The reaction was directly spin-dried and purified by column chromatography to give Compound IV as a white foamy solid 62g, yield 81.39%;
References:
CN107586280,2018,A Location in patent:Paragraph 0031; 0039
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![1,4,8,11-Tetraazacy clotetradecance, 1,4,8-tris[(4 Methylphenyl)sufonyl]-](/CAS/20150408/GIF/104395-69-9.gif)
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