Propitocaine hydrochloride synthesis
- Product Name:Propitocaine hydrochloride
- CAS Number:1786-81-8
- Molecular formula:C13H21ClN2O
- Molecular Weight:256.77
721-50-6
417 suppliers
$12.00/1mg
1786-81-8
352 suppliers
$39.00/1mg
Yield:1786-81-8 96%
Reaction Conditions:
with hydrogenchloride in water;ethyl acetate; pH=1;
Steps:
1
(C) 100g prilocaine dissolved in 500 ml of ethyl acetate, adjusting PH=1 dropping concentrated hydrochloric acid, a large amount of solid precipitated, the filtration filters cake washing several times with acetone, drained, solid 70 °C vacuum drying, get hydrochloric acid prilocaine about 96 g, yield of 96.0%. Measuring its melting point the 167-168.0 °C. Content measured by HPLC for 99.96%.
References:
CN104529812,2016,B Location in patent:Paragraph 0054
107-10-8
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$10.00/20mg
7623-09-8
271 suppliers
$40.00/10g
95-53-4
427 suppliers
$10.00/1g
1786-81-8
352 suppliers
$39.00/1mg