ChemicalBook CAS DataBase List Rabeprazole Sodium

Rabeprazole Sodium synthesis

6synthesis methods

Product Name:Rabeprazole Sodium
CAS Number:117976-90-6
Molecular formula:C18H21N3O3S.Na
Molecular Weight:382.43

117976-89-3

117976-90-6

Example 2: Sodium hydroxide (2.25 g, 55.1 mmol) was dissolved in ethanol (30 ml) and stirred until completely dissolved. Subsequently, 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole (20.0 g, 55.6 mmol) was added to this solution and stirred until completely dissolved. After confirmation of dissolution, diisopropyl ether (2000 ml) was slowly added to induce precipitation of the target product 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazole-1-ide sodium salt. The precipitate was collected by filtration to give 22.8 g of product in 100% yield. Example 3: Sodium hydroxide (1.65 g, 41.3 mmol) was dissolved in ethanol (22.5 ml) and stirred until completely dissolved. Then, 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole (15.0 g, 41.7 mmol) was added to this solution and stirred until completely dissolved. After confirmation of dissolution, tert-butyl methyl ether (160 ml) was slowly added to induce precipitation of the target product 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazole-1-ide sodium salt. The precipitate was collected by filtration to give 15.9 g of product in 100% yield.

117976-89-3 Synthesis

117976-89-3
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$15.00/1mg

117976-90-6
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$25.00/5mg

Yield:117976-90-6 100%

Reaction Conditions:

with sodium hydroxide in ethanolProduct distribution / selectivity;

Steps:

2; 3
Example 2 Ethanol (30 ml) was added to sodium hydroxide (2.25 g (55.1 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (20.0 g (55.6 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, diisopropyl ether (2000 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (22.8 g) was obtained through precipitation (yield 100%).; Example 3 Ethanol (22.5 ml) was added to sodium hydroxide (1.65 g (41.3 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (15.0 g (41.7 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, tert-butyl methyl ether (160 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (15.9 g) was obtained through precipitation (yield 100%).

References:

Urawa, Yoshio US2007/225502, 2007, A1 Location in patent:Page/Page column 5

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